Identifying biophysical assays and in silico properties that enrich for slow clearance in clinical-stage therapeutic antibodies.
In-silico drug repurposing study: Amprenavir, enalaprilat, and plerixafor, potential drugs for destabilizing the SARS-CoV-2 S-protein-angiotensin-converting enzyme 2 complex.
Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis-Addicted Breast Tumor Growth.
A deep learning framework for drug repurposing via emulating clinical trials on real-world patient data.
Multi-omics study for interpretation of genome-wide association study.
The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions.
Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Pharmacology-informed prediction of the risk posed to fish by mixtures of non-steroidal anti-inflammatory drugs (NSAIDs) in the environment.
Exploring the mechanism of Yizhi Tongmai decoction in the treatment of vascular dementia through network pharmacology and molecular docking.
A Multi-Omics Analysis of PON1 Lactonase Activity in Relation to Human Health and Disease.