• log P
  • Partition coefficient

LogP is directly related to the drug lipophilicity which is a key property for the solubility, absorption, membrane penetration, plasma protein binding, distribution, and tissue penetration. Due to the importance of the drug lipophilicity, logP is a component of the Lipinski rule of five.1

LogP is defined as the partition coefficient of a molecule between aqueous and lipophilic phases usually considered as octanol and water. It is determined experimentally by dissolving the compound in an immiscible biphasic system of lipids and water in order to determine the proportion of solute dissolved in each phase.2

In DrugBank, it is possible to find the experimental and predicted value of logP. 


  1. Cambridge MedChem Consulting [Link]
  2. Advanced chemistry development [Link]