Severity for drug interactions is classified as minor, moderate, or major.

  • Risk Level: Observe and adjust
  • Description: These medications may interact in a clinically significant manner, however, the benefits of concomitant use usually outweigh any risks. A monitoring plan should be put in place and dosage adjustments may be needed.

  • Risk Level: Adjustment should be considered
  • Description: The benefits of continuing concomitant therapy should be evaluated on an individual basis. Actions such as aggressive observation, dosage changes, or alternative medications may need to be taken.

  • Risk Level: Combination should be avoided
  • Description: Concomitant therapy with this combination may cause more harm than benefit and alternative medications or means of therapy should be employed.